فایل Drug disposition توزيع دارو ها به زبان انگلیسی (رشته دارو سازی)

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فایل Drug disposition توزيع دارو ها به زبان انگلیسی (رشته دارو سازی)
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فایل Drug disposition توزيع دارو ها به زبان انگلیسی (رشته دارو سازی) در قالب pdf و در حجم 123 اسلاید:

بخشی از متن:
Drug disposition is what happens to a chemical after it enters the body. • After oral dosing, drug disposition (ADME) includes absorption from the gastrointestinal tract into central circulation; distribution to and between various tissues; metabolism to different chemicals; and excretion (usually in urine or feces).
Drug distribution is the reversible transport of a drug from one part of the body to another. • Usually is used to describe the translocation of drug from blood stream to tissue. • Distribution is generally uneven because of differences in blood perfusion, tissue binding (e.g., because of lipid content), regional pH, and permeability of cell membranes. • Steady-state is the term employed when the 
concentration of drug in all parts of the body are constant. 
Distribution Compartments • 1. Central Compartment, includes the well-perfused organs and tissues (heart, blood, liver, brain and kidney) which drug equilibrates rapidly. • 2. Peripheral Compartment(s), include(s) those organs (e.g., adipose and skeletal muscle) which are less well-perfused, and drug therefore equilibrates more slowly. Redistribution from one compartment to another often alters the duration of effect at the target tissue. • 3. Special Compartments, Entry of drug into the cerebrospinal fluid (CSF) and central nervous system (CNS) is restricted by the structure of the capillaries and pericapillary glial cells. Drugs also have relatively poor access to pericardial fluid, bronchial secretions and fluid in the middle ear. 

فهرست مطالب:
Drug Distribution
Distribution Compartments
Rate and Extent of Distribution
Physiologic Factors of Distribution 
Blood circulatory system 
Distribution in blood and other fluids
Distribution Spaces
Determinants of Drug Distribution
Cell membranes
Plasma Drug Concentration:
Main process of drug crossing the
capillary
Passive diffusion
Fick's law of diffusion
Hydrostatic pressure
At the arterial end 
At the venous end:
Permeability of Cell and Capillary
Membranes
Liver vs Brain
Alteration of permeability:
Cellular Distribution
Cellular Membrane
Cellular transport machinery
Passive transport 
Passive diffusion 
Weak Acidic and Basic drugs 
Drug penetration to the CNS 
Secretion of drug into milk
  Major macromolecular components in the blood
Albumin,
 α1-acid glycoprotein,
 lipoproteins,
Erythrocytes
Procainamide Concentration in Dog Myocardium
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برچسب ها: Drug disposition پاورپوینت توزيع دارو رشته دارو سازیتحقیق توزيع دارو مقاله توزيع دارو جزوه توزيع دارو پاورپوینت Drug disposition Drug DistributionDistribution CompartmentsRate and Extent of DistributionPhysiologic Factors of Distr